Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response
Idalba Serrato-Pomar, Hacène Medkour, Louise Belleville, Kachaporn Jintana, Lauryne Pruvost, Norman Schneider, Mihra Tavadia, Jim Zoladek, Florian Rachenne, Zoé Roux, Quentin Narpon, Félix Rey-Cadilhac, Solena Rossi, Stephanie French, Cassandra Marie Modahl, , Julien Pompon
This study identifies sfRNA in mosquito saliva that enhances orthoflavivirus transmission by inhibiting MDA5-mediated interferon response in human skin cells.
Nature Communications · Aug 29, 2026Peer-reviewedImmunology