Hacène Medkour

Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response

This study identifies sfRNA in mosquito saliva that enhances orthoflavivirus transmission by inhibiting MDA5-mediated interferon response in human skin cells.

Single-cell characterization of skin response to a bite by West Nile virus-infected mosquito reveals fibroblast-mediated barrier to transmission

This study uses single-cell RNA-sequencing to analyze skin responses to West Nile virus-infected mosquito bites, identifying fibroblasts as key cells restricting viral transmission.

Sphingomyelins in mosquito saliva modify the host lipidome to enhance transmission of flaviviruses by promoting viral protein levels

This study identifies sphingomyelins in mosquito salivary extracellular vesicles that enhance flavivirus transmission by altering the host lipidome and increasing viral protein levels.

Arboviruses disrupt salivary gland organization and decrease salivation in Aedes aegypti mosquitoes

This study shows that arboviruses reduce salivation in Aedes aegypti mosquitoes by disrupting salivary gland organization, potentially enhancing virus transmission.