PRC2 Restricts Malignant Peripheral Nerve Sheath Tumorigenesis in a Genetically Engineered Mouse Model of MPNST
Woo Hyun Cho, Amish J. Patel, Makzhuna Khudoynazarova, Sarah Warda, Juan Yan, Dan Li, Dana M. Schoeps, Eve Fishinevich, Mohini R. Pachai, Cindy J. Lee, Zoe Jacobs, Kae Kristoff, Jessica J. Sher, Cristina R. Antonescu, Yu Chen, Ping Chi
This study shows that PRC2 inactivation promotes MPNST by reprogramming Schwann-lineage cells and presents a mouse model that recapitulates human PRC2-loss MPNST.
bioRxiv · Nov 12, 2025 · PreprintCancer Biology