BiochemistrybioRxivPreprint
In-source fragmentation in mass spectrometry-based proteomics: prevalence, impact, and strategies for mitigation
Thorben Schramm, Ludovic C. J. Gillet, Viviane Reber…·Paola Picotti
The paper identifies and quantifies in-source fragmentation (ISF) in proteomics data, showing its prevalence and impact, and proposes an open-source method to detect and remove ISF peptides.
DOI 10.64898/2026.03.27.714398