Viviane Reber

The paper shows that BAY-805 induces USP21-KLHL12 association, recruiting USP21 to COPII vesicles and impairing large cargo transport.

The paper identifies inhibitor-induced structural changes in kinases that drive non-catalytic effects, revealing the ATP-binding site as a key regulator of kinase conformation and interactions.

This study shows that alpha-synuclein fibrils cause mitochondrial-derived vesicle budding and structural changes in mitochondria, linking alpha-synuclein aggregation to mitochondrial toxicity.

The paper identifies and quantifies in-source fragmentation (ISF) in proteomics data, showing its prevalence and impact, and proposes an open-source method to detect and remove ISF peptides.

This study identifies structural and functional differences in alpha-synuclein fibrils from Parkinson's disease, Dementia with Lewy Bodies, and Multiple System Atrophy, linking these differences to disease-specific cellular responses and potential therapeutic targets.

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.