Jill R. Crittenden

MECP2-mutant marmosets exhibit primate-specific phenotypes of Rett syndrome

This study generates MECP2-knockout marmosets to model Rett syndrome, revealing cortical structural and gene expression changes linked to the disease.

State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease

This study identifies state-dependent modulation of spiny projection neurons in a mouse Parkinson's model and shows how disrupting specific signaling pathways reduces levodopa-induced dyskinesia.

Molecular unbalances between striosome and matrix compartments characterize the pathogenesis of Huntington's disease model mouse

The paper uses machine learning to analyze striosome and matrix compartments in Huntington's disease model mice, revealing age-related molecular differences that may explain disease pathogenesis.

Developmental and adult striatal patterning of nociceptin ligand marks striosomal population with direct dopamine projections

The paper identifies striosomal populations in the dorsal striatum expressing Pnoc mRNA, which are dopamine receptor D1-expressing medium spiny neurons with direct projections to midbrain dopamine neurons.

Striosomes Target Nigral Dopamine-Containing Neurons via Direct-D1 and Indirect-D2 Pathways Paralleling Classic Direct-Indirect Basal Ganglia Systems

The paper identifies striosomal pathways that target substantia nigra dopamine neurons, with opposite effects on movement compared to canonical pathways.

Huntington's Disease Produces Multiplexed Transcriptional Vulnerabilities of StriatalD1-D2 and Striosome-Matrix Neurons

The paper examines transcriptional changes in striatal neurons in Huntington's disease, finding that striosomal SPNs are most depleted and compartmental markers are dysregulated in both mouse models and human HD.

Cannabinoid receptor 1 is required for neurodevelopment of striosome-dendron bouquets

This study shows that CB1R is essential for the postnatal development of striosome-dendron bouquets, which are critical for dopamine system connectivity, and suggests potential developmental risks from maternal use of CB1R agonists or antagonists.

Effects of acute and repeated administration of the selective M4 PAM VU0152099 on cocaine vs. food choice in male rats

This study examines the effects of repeated M4 PAM VU0152099 administration on cocaine vs. food choice in rats, finding progressive suppression of cocaine choice without rebound or lasting effects.

Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human

This study identifies CalDAG-GEFI mutations causing psychomotor symptoms and bleeding in multiple species, revealing conserved signaling deficits in striatal function.

Drosophila mef2 is essential for normal mushroom body and wing development.

This study shows that Drosophila MEF2 is critical for mushroom body and wing development, with specific roles in dopamine-receptive neurons.