Author

James Wellnitz

University of North Carolina at Chapel HillORCID 0000-0002-9181-3431Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Research Focus:benchmarking· 2 Research Focus:database / resource· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Brandon NovyiD· 2 shared Devan J. ShelliD· 2 shared Eric M. MerteniD· 2 shared Ivanna ZhilinskayaiD· 2 shared Kenneth H. PearceiD· 2 shared Konstantin I. PopoviD· 2 shared P. Brian Hardy· 2 shared Shu-Hang LiniD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBioinformatics

Brandon NovyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Open-Source DNA-Encoded Library Package for Design, Decoding, and Analysis: DELi

James Wellnitz, Brandon Novy, Shu-Hang Lin, Travis Maxfield, Matthew Axtman, Tina M. Leisner, Eric M. Merten, Ivanna Zhilinskaya, Devan J. Shell, Kellyn M. Schroeder, Jacqueline L. Norris-Drouin, P. Brian Hardy, Kenneth H. Pearce, Konstantin I. Popov

DELi is an open-source platform for DNA-encoded library design, decoding, and analysis, demonstrating its effectiveness through the identification of a BRD4 binder.

Journal of Cheminformatics · Sep 4, 2026Peer-reviewedBioinformatics

Expansion of DNA-Encoded Library Hits Using Generative Chemistry and Ultra-Large Compound Catalogs

Brandon Novy, Shu-Hang Lin, Devan J. Shell, Travis Maxfield, Eric M. Merten, Ivanna Zhilinskaya, James Wellnitz, Shiva Krishna Reddy Guduru, P. Brian Hardy, Kenneth H. Pearce, Konstantin I. Popov

This paper combines DNA-encoded libraries with generative AI to expand hit compounds, finding AI-selected hits show better drug-likeness and diversity than initial DEL hits.

bioRxiv · Sep 30, 2025 · PreprintBiophysics

Heli-SMACC: Helicase-targeting SMAll Molecule Compound Collection

Holli‐Joi Martin, Mohammad Anwar Hossain, James Wellnitz, Enes Kelestemur, Joshua E. Hochuli, Sumera Parveen, C.H. Arrowsmith, Timothy Mark Willson, Eugene N. Muratov, Alexander Tropsha

The paper curates a database of helicase inhibitors, Heli-SMACC, and tests selected compounds against SARS-CoV-2 NSP13 ATPase, finding twelve inhibitors with dose-response activity.

bioRxiv · Jul 4, 2024 · PreprintBioinformatics