Linda Julian

This study reveals that PAC-1, a clinical-stage oncology compound, targets drug-resistant cancers by disrupting iron homeostasis and exploiting MDR1 expression to induce iron depletion.

This study shows CDK11 is critical for cancer cell survival and identifies 1p36 deletions as a biomarker for CDK11 inhibitor sensitivity, but on-target toxicity limits therapeutic efficacy.

This study shows that expressing caspase-resistant ROCK1 in B cell lymphoma mice prolongs survival by reducing cell numbers and creating a proliferation-suppressive bone marrow microenvironment.