Eric van Genderen

This study shows that replacing H2O with D2O in cryo-EM increases radiation tolerance in protein crystals by reducing recoil energy and bond breakage.

This study shows that narrow-beam geometry in cryo-EM reduces radiation damage and improves signal-to-noise ratio by capturing diffraction patterns from biological specimens.

DiffGAN estimates missing phases in single molecule cryo-electron diffraction data to determine protein structures at atomic resolution using a conditional GAN.

The paper improves protein nanocrystal refinement by statistically correcting dynamical electron scattering, enabling better structural and charge state determination.