Jan Pieter Abrahams

This study shows that replacing H2O with D2O in cryo-EM increases radiation tolerance in protein crystals by reducing recoil energy and bond breakage.

Diffractograph reconstructs 3D structures from single-particle electron diffraction data by selecting compatible frames and determining orientations, achieving accurate results on synthetic data.

CryoConvNeXt improves identification of low-abundance molecular species in cryo-EM data by using deep learning with self-training, outperforming conventional methods in minority-species recall.

This study shows that narrow-beam geometry in cryo-EM reduces radiation damage and improves signal-to-noise ratio by capturing diffraction patterns from biological specimens.

This paper investigates how LonP1 protease uses ATP hydrolysis to regulate substrate translocation and proteolytic activation, showing that proteolysis of folded proteins requires ATP-driven unfolding and translocation.

The paper shows that human mitochondrial Lon protease degrades substrates starting from either terminus, with unidirectional processing, and provides structural and biochemical evidence for this mechanism.

This paper shows LonP1 inhibits fibrillar aggregate growth without ATPase activity, localizing chaperone function to its N-domain hexamer.

This paper identifies a novel aminosugar metabolic pathway in Streptomyces that regulates development and antibiotic production through GlcNAc sensing.

DiffGAN estimates missing phases in single molecule cryo-electron diffraction data to determine protein structures at atomic resolution using a conditional GAN.

The paper improves protein nanocrystal refinement by statistically correcting dynamical electron scattering, enabling better structural and charge state determination.

The paper shows that mutations in SsgB, a protein that recruits FtsZ, cause longitudinal cell division in Streptomyces by altering septum placement.