Uwe Plessmann

The paper uses proteogenomics to assess CUG codon mistranslation in Candida albicans and finds no evidence of leucine mistranslation, instead showing ribosomal-level ambiguity and no correlation with pathogenicity.

The paper identifies a novel sense codon reassignment in Pachysolen tannophilus, where CUG is translated as alanine instead of leucine, and proposes a tRNA loss-driven mechanism for this genetic code alteration.