Author
European Bioinformatics InstituteORCID 0000-0001-5057-0210Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Valentina Iotchkova, Michael E. Weale
The paper introduces MystraColoc, a Bayesian algorithm for multi-trait colocalisation, showing improved performance in clustering genetic association signals across GWAS datasets.
Josine L. Min, Gibran Hemani, Eilis J. Hannon…·Marinus H. van IJzendoorn
The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.
Stephen B. Watt, Louella J. Vasquez, Klaudia Walter…·Nicole Soranzo
The paper identifies how variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility and cell count differences.
Simon J. Haworth, Chin Yang Shapland, Caroline Hayward…·David K. Jackson
The paper identifies 9 novel genetic loci, including low-frequency variants in TP53, associated with head circumference and intracranial volume in up to 46,000 individuals.
Daniel Rico, Joost H.A. Martens, Kate Downes…·Hendrik G. Stunnenberg
This study compares the epigenomes of neutrophils and monocytes to identify regulatory elements and chromatin states, revealing differences in enhancer activity and DNA methylation.
Valentina Iotchkova, Graham R. S. Ritchie, Matthias Geihs…·Nicole Soranzo
The paper introduces a method to assess enrichment of GWAS loci in regulatory regions, identifying novel biological insights across 27 traits.
Ian Dunham, Eugene Kulesha, Valentina Iotchkova…·Ewan Birney
FORGE identifies tissue-specific regulatory enrichments of GWAS SNPs by analyzing overlaps with DNase I hotspots from diverse tissues.
Dragana Vuckovic, Paolo Gasparini, Nicole Soranzo, Valentina Iotchkova
MultiMeta performs meta-analysis of multi-phenotype GWAS by combining results from different cohorts using an inverse-variance based method in an n-dimensional setting.