Ian Dunham

VIDRA models genetic dose-response relationships to predict drug mechanisms, therapeutic potential, and adverse events using phenotypically associated variants.

FORGEdb integrates genomic annotations to prioritize functional variants and target genes for complex diseases.

The paper identifies 995 genes with shared genetic links to age-related diseases using GWAS data and presents them in a web tool for drug target prioritization.

The paper uses network-based expansion of GWAS results to identify pleiotropic gene modules linked to multiple traits and demonstrates their application in studying inflammatory bowel disease.

The paper analyzes reasons for clinical trial failures using NLP and shows that genetic evidence improves trial success chances.

This study uses multi-ancestry Mendelian randomization to identify six protein targets for COVID-19 severity, showing ancestry-specific effects.

This study identifies 13 genome-wide significant loci associated with SARS-CoV-2 infection or severe COVID-19 through a global meta-analysis of 49,562 patients.

The paper presents an open resource for fine-mapping and gene prioritization at GWAS loci, identifying causal variants and genes and improving drug target identification.

The paper identifies immune disease variants affecting Treg gene expression and highlights potential drug targets by linking GWAS signals with Treg QTLs.

The paper identifies 9 novel genetic loci, including low-frequency variants in TP53, associated with head circumference and intracranial volume in up to 46,000 individuals.

The paper describes the design of an intuitive web application for drug discovery scientists to improve data utilization and research advancement.

This study compares the epigenomes of neutrophils and monocytes to identify regulatory elements and chromatin states, revealing differences in enhancer activity and DNA methylation.

The paper describes a literature mining component of the Open Targets platform that identifies and ranks target-disease associations from PubMed and Open Access articles.

The paper proposes the Human Cell Atlas project to catalog all human cell types through molecular profiling and connects this data with classical cellular descriptions.

The paper introduces a method to assess enrichment of GWAS loci in regulatory regions, identifying novel biological insights across 27 traits.

FORGE identifies tissue-specific regulatory enrichments of GWAS SNPs by analyzing overlaps with DNase I hotspots from diverse tissues.