Author

Mélina Blanco

Centre National de la Recherche ScientifiqueORCID 0000-0001-5057-4334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:ChIP-seq· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alberto de la IglesiaiD· 2 shared Clara GobéiD· 2 shared Clémentine Lapoujade· 2 shared Côme Ialy‐RadioiD· 2 shared Julie CocquetiD· 2 shared Laïla El KhattabiiD· 2 shared Manon CouléeiD· 2 shared Pierre FouchetiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Alberto de la IglesiaORCID

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2 papers

Recent·Most cited

Molecular BiologyCommunications BiologyPeer-reviewedJan 28, 2025

Chromatin Environment-Dependent Effects of DOT1L on Gene Expression in Male Germ Cells

Manon Coulée, Alberto de la Iglesia, Mélina Blanco…·Laïla El Khattabi

This study shows that DOT1L has opposing effects on gene expression in mouse spermatogenesis depending on chromatin environment, repressing some genes and activating others, particularly on the X chromosome.

2 citations

mousebulk RNA-seq

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Molecular BiologyEMBO ReportsPeer-reviewedApr 26, 2023

The histone methyltransferase DOT1L regulates chromatin reorganization and gene expression during the postmeiotic differentiation of male germ cells

Mélina Blanco, Laïla El Khattabi, Clara Gobé…·Julie Cocquet

This study shows that DOT1L regulates chromatin reorganization and gene expression in male germ cells, leading to fertility defects in its absence.

22 citationstop 4%

mouseproteomics

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