Pierre Fouchet

Chromatin Environment-Dependent Effects of DOT1L on Gene Expression in Male Germ Cells

This study shows that DOT1L has opposing effects on gene expression in mouse spermatogenesis depending on chromatin environment, repressing some genes and activating others, particularly on the X chromosome.

Characterization and hierarchy of the spermatogonial stem cell compartment in human spermatogenesis by spectral cytometry using a 16-colors panel

The paper identifies novel markers of human spermatogonial stem cells using spectral cytometry and defines their hierarchy in spermatogenesis.

The histone methyltransferase DOT1L regulates chromatin reorganization and gene expression during the postmeiotic differentiation of male germ cells

This study shows that DOT1L regulates chromatin reorganization and gene expression in male germ cells, leading to fertility defects in its absence.

DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis

This study shows that DNMT3A-dependent DNA methylation is essential for spermatogonial stem cells to commit to differentiation and spermatogenesis.

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

This study identifies EZHIP as a novel cofactor of PRC2 that limits its activity in germ cells, leading to altered H3K27me2/3 deposition and impaired fertility in female mice.

Single-cell RNA-Seq Resolves Cellular Heterogeneity and Transcriptional Dynamics in Spermatogonial Stem Cells Establishment

This study uses single-cell RNA sequencing to analyze spermatogonial stem cell establishment in mice, identifying key molecular transitions and novel markers.