Côme Ialy‐Radio

This study shows that DOT1L has opposing effects on gene expression in mouse spermatogenesis depending on chromatin environment, repressing some genes and activating others, particularly on the X chromosome.

This study shows that DOT1L regulates chromatin reorganization and gene expression in male germ cells, leading to fertility defects in its absence.

The paper shows that X-bearing sperm have greater motility than Y-bearing sperm in mice with Yq deletions, leading to a skewed sex ratio.