Author

Alberto de la Iglesia

Centre National de la Recherche ScientifiqueORCID 0000-0003-3475-2086Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Julie CocquetiD· 3 shared Clara GobéiD· 2 shared Clémentine Lapoujade· 2 shared Côme Ialy‐RadioiD· 2 shared Delphine PfliegeriD· 2 shared Laïla El KhattabiiD· 2 shared Manon CouléeiD· 2 shared Mélina BlancoiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Julie CocquetORCID

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3 papers

Recent·Most cited

Both L-lactyl and D-lactyl enantiomers modify histones in mouse testis

Julie Manessier, Hassan Hijazi, Lisa Vizzini, Sabine Brugière, Marie Courçon, Christophe Masselon, Alberto de la Iglesia, Julie Cocquet, Delphine Pflieger

The paper identifies L- and D-lactylation on histones H3 and H4 in mouse testis using proteomics and shows site-specific enantiomer preferences.

Molecular & Cellular Proteomics · Jun 13, 2026Peer-reviewedBiochemistry

Chromatin Environment-Dependent Effects of DOT1L on Gene Expression in Male Germ Cells

Manon Coulée, Alberto de la Iglesia, Mélina Blanco, Clara Gobé, Clémentine Lapoujade, Côme Ialy‐Radio, Lucía Álvarez-González, Guillaume Meurice, Aurora Ruiz‐Herrera, Pierre Fouchet, Julie Cocquet, Laïla El Khattabi

This study shows that DOT1L has opposing effects on gene expression in mouse spermatogenesis depending on chromatin environment, repressing some genes and activating others, particularly on the X chromosome.

Communications Biology · Jan 28, 2025Peer-reviewedMolecular Biology

The histone methyltransferase DOT1L regulates chromatin reorganization and gene expression during the postmeiotic differentiation of male germ cells

Mélina Blanco, Laïla El Khattabi, Clara Gobé, Marion Crespo, Manon Coulée, Alberto de la Iglesia, Côme Ialy‐Radio, Clémentine Lapoujade, Maëlle Givelet, Marion Delessard, Ivan Seller‐Corona, Kosuke Yamaguchi, Nadège Vernet, Fred van Leeuwen, Alban Lermine, , Julie Cocquet

This study shows that DOT1L regulates chromatin reorganization and gene expression in male germ cells, leading to fertility defects in its absence.

EMBO Reports · Apr 26, 2023Peer-reviewedMolecular Biology