Author

Pearlly S. Yan

The Ohio State UniversityORCID 0000-0003-1965-4920Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Altan M. TurkogluiD· 2 shared Elizabeth D. KirbyiD· 2 shared Jiyeon K. DenningeriD· 2 shared Olga N. Kokiko‐CochraniD· 2 shared Abbey A. SaadeyiD· 1 shared Abby R. Volk· 1 shared Alex Pan· 1 shared Amal O. AmeriD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Altan M. TurkogluORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 30, 2023

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease

Kylene P. Daily, Asmaa Badr, Mostafa M. Eltobgy…·Amal O. Amer

This study identifies DNA hypomethylation of CASP4 in AD microglia leading to increased CASP4 expression, which promotes neuroinflammation and amyloid-β deposition in Alzheimer's disease.

4 citations

humanmouse

𝕏 PostBluesky

NeuroscienceFrontiers in Molecular NeurosciencePeer-reviewedJan 31, 2022

Robust transcriptional profiling and identification of differentially expressed genes with low input RNA sequencing of adult hippocampal neural stem and progenitor populations

Jiyeon K. Denninger, Logan A. Walker, Xi Xian Chen…·Elizabeth D. Kirby

This study compares bulk and single-cell RNAseq for identifying differentially expressed genes in adult hippocampal NSCs, finding single-cell methods miss high-fold-change genes but can be optimized for in vivo use.

20 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeuroscienceBrain ResearchPeer-reviewedFeb 6, 2020

Defining the adult hippocampal neural stem cell secretome: in vivo versus in vitro transcriptomic differences and their correlation to secreted protein levels

Jiyeon K. Denninger, Xi Chen, Altan M. Turkoglu…·Elizabeth D. Kirby

The paper compares in vitro and in vivo transcriptomic and proteomic profiles of adult hippocampal NSPCs, finding discrepancies in secreted protein abundance and gene expression.

20 citations

mousebulk RNA-seq

𝕏 PostBluesky