Thomas Kurth

This study identifies mTOR signaling as a central regulator of zebrafish heart regeneration, showing its dual role in promoting cardiomyocyte proliferation and regulating autophagy.

This study compares human iPSC-derived photoreceptors of different ages for transplantation into a mouse retinal degeneration model, showing structural integration and functional maturation.

This study shows that transplanted human photoreceptors integrate and mature better in mildly degenerated retinas than severely degenerated ones, depending on the retinal microenvironment.

This paper shows that Heparan Sulfate Proteoglycans (HSPGs) in the extracellular matrix bind Fgf8, altering its diffusion and signaling, and contribute to forming the Fgf8 morphogen gradient.

This study reveals the structural and spatial organization of beta cell primary cilia in mouse and human islets, showing their interactions with neighboring cells and nerves, and their role in islet connectivity.

The paper shows that passage 1 human iPSC-derived RPE cells form more extensive monolayers after transplantation compared to passage 2 cells, highlighting a subpopulation with higher transplantation potential.

The paper shows that vertebral segmentation during axolotl tail regeneration occurs via a buckling instability mechanism, distinct from the somite-based process in embryonic development.

The paper investigates cell lineage relationships in zebrafish fin regeneration using single-cell RNA sequencing and lineage tracing, revealing compartmentalized osteoblast and blastema contributions to bone formation.

This study shows that human photoreceptor cells transplanted into human retina organoids integrate structurally, forming clusters with cone and rod photoreceptors and host cell contacts.

This study maps β-cell regeneration in zebrafish using single-cell transcriptomics, identifying hybrid β/δ cells as key contributors to diabetes recovery.

This paper demonstrates that transplanted human photoreceptors from iPSC retinal organoids extensively incorporate into a murine cone degeneration model, leading to improved maturation, polarisation, and functional integration.

This study shows that IL4 restores neurogenic plasticity of human NSCs by suppressing KAT2, which is upregulated in AD mouse models.