Michael A. O’Reilly

This study shows that neonatal hyperoxia inhibits atrial cardiomyocyte proliferation by suppressing fatty acid synthesis genes, leading to diastolic heart failure.

The paper shows that neonatal hyperoxia increases age-dependent expression of SARS-CoV-2 receptors in mice, potentially explaining higher COVID-19 severity in the elderly and those with pre-existing conditions.

The paper uses single-cell RNA-seq to identify Krt8+ progenitor cells involved in lung regeneration and shows their role in epithelial differentiation and disease.