The paper shows how chiral multicellular patterns arise from actin self-organisation in cells, with chiral order starting at tissue boundaries and propagating inward.

bioRxiv · Oct 14, 2025 · PreprintBiophysics

Dual-mode tethered intramolecular agonist-dependent mechanoactivation of the adhesion GPCR ADGRG1/GPR56

Chaoyu Fu, Cheng Quan, Lina Zielke, Yuan Weng, Ying Zhang, Gaojie Song, Tobias Langenhan, Jie Yan

This study investigates the mechanotransduction mechanism of ADGRG1/GPR56, revealing a dual-mode activation process that does not require NTF-CTF dissociation and depends on the Stachel element.

bioRxiv · Sep 16, 2025 · PreprintCell Biology

Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth

Ying Zhang, Kaijing Chen, Seng Chuan Tang, Yichao Cai, Akiko Niibori-Nambu, Yi Xiang See, Chaoyu Fu, Anandhkumar Raju, Benjamin Lebeau, Zixun Ling, Jia Jia Chan, Yvonne Tay, Marek Mutwil, Manikandan Lakshmanan, Greg Tucker‐Kellogg, , Melissa J. Fullwood

The paper demonstrates that disrupting super-silencers via EZH2 and REST inhibition reduces chromatin interactions and cancer growth.

Nature Structural & Molecular Biology · Sep 20, 2024Peer-reviewedMolecular Biology

Super-silencers regulated by chromatin interactions control apoptotic genes

Ying Zhang, Kaijing Chen, Yichao Cai, Akiko Niibori-Nambu, Yi Xiang See, Chaoyu Fu, Anandhkumar Raju, Manikandan Lakshmanan, Motomi Osato, Vinay Tergaonkar, Melissa J. Fullwood

The paper identifies 'super-silencers' formed by chromatin interactions that regulate apoptotic genes and shows that combining GSK343 and X5050 disrupts these silencers to induce antitumor effects.

bioRxiv · Jan 17, 2022 · PreprintGenomics