Honglin Chen

This study shows that target RNA abundance controls collateral activity of RfxCas13d in human cells and zebrafish embryos, with high abundance causing widespread degradation and toxicity.

This study designs AI-generated anti-CRISPR proteins that inhibit CRISPR-Cas13 with high potency and specificity.

This study compares RNA knockdown profiles of small RNA and Cas13 systems to identify structural rules governing target-site selection.

This study shows SARS-CoV-2 infects sensory neurons via ACE2 and TRPV1, causing axonal damage, and that TRPV1 antagonists can protect neurons.

This study introduces a statistical framework to estimate the nuclear export rate of influenza viral mRNA segments using imaging data and reveals that hemagglutinin and neuraminidase segments are the slowest.

This paper introduces CRISPR-PspCas13b as a method to systematically silence oncogenic fusion transcripts, showing effectiveness against drug-resistant cancer drivers.

This study shows SARS-CoV-2 infection in hamsters causes persistent lung inflammation and alveolar-bronchiolization linked to Notch signaling dysregulation and potential cancer risk.

The paper uses CUT&RUN to identify distinct DNA footprints of RNA polymerase II near transcription start sites, revealing transient positioning before promoter-proximal pausing.