Cyntia Taveneau

tRNA-derived second messengers confer bacterial immunity

The paper identifies a bacterial immune pathway where tRNA cleavage generates second messengers that trigger cell death via RNA-guided nuclease activity.

De novo design of potent CRISPR-Cas13 inhibitors

This study designs AI-generated anti-CRISPR proteins that inhibit CRISPR-Cas13 with high potency and specificity.

Structures of tRNA-bound CRISPR-Cas13 reveal universal HEPN RNase mechanisms

The paper determines the structure of tRNA-bound CRISPR-Cas13 and reveals universal HEPN RNase mechanisms for substrate recognition and catalysis.

Obtaining high-resolution cryo-EM structures using a common LaB6, 120-keV electron microscope equipped with a sub 200-keV optimised direct electron detector.

This paper demonstrates that a standard 120-keV TEM with a direct electron detector can achieve high-resolution cryo-EM reconstructions of various proteins.