Harry Dempsey

This study shows that hunger-sensitive AgRP neurons in the hypothalamus are inhibited by threats, leading to avoidance behavior through GABAergic inputs from DMH neurons.

The paper identifies sex differences in neural circuits driving binge drinking, finding a female-specific role for the amygdalo-striatal pathway in alcohol misuse.

This study examines sex differences in approach-avoidance behaviors in fasted and sated male and female mice across various tasks, revealing nuanced differences in decision-making under different reward and threat conditions.

This study shows that GHSRs in the olfactory bulb link hunger to olfactory sensitivity, affecting food-seeking and metabolism in mice.

This study shows that metabolic sensing in AgRP neurons is essential for dopamine release in the nucleus accumbens in response to caloric solutions and influences sucrose preference under hunger.

This study shows that ghrelin signaling in AgRP neurons integrates energy need with sensory cues to regulate AgRP activity and dopamine release in response to food.

This study shows that AgRP neurons regulate context-induced feeding through precise temporal firing patterns during context exposure.

The paper identifies a stress-sensitive anorexigenic pathway from the medial prefrontal cortex to the lateral hypothalamus in mice and shows its role in regulating food intake during stress.

This study shows that impaired metabolic-sensing in AgRP neurons reduces dopamine release in the dorsal striatum and suppresses reward-seeking behavior, especially under hunger.