Mathieu Méquinion

Temporal regulation of AgRP neurons mediates context-induced feeding

This study shows that AgRP neurons regulate context-induced feeding through precise temporal firing patterns during context exposure.

Identification of a stress-sensitive anorexigenic neurocircuit from medial prefrontal cortex to lateral hypothalamus.

The paper identifies a stress-sensitive anorexigenic pathway from the medial prefrontal cortex to the lateral hypothalamus in mice and shows its role in regulating food intake during stress.

Metabolic-sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum

This study shows that impaired metabolic-sensing in AgRP neurons reduces dopamine release in the dorsal striatum and suppresses reward-seeking behavior, especially under hunger.

Circulating unacylated-ghrelin impairs hippocampal neurogenesis and memory in mice and is altered in human Parkinson’s disease dementia

The paper shows that elevated circulating unacylated-ghrelin impairs hippocampal neurogenesis and memory in mice and is associated with reduced AG:UAG ratio in Parkinson’s disease dementia patients.