Sarah Haas Lockie

This study shows that ghrelin signaling in AgRP neurons integrates energy need with sensory cues to regulate AgRP activity and dopamine release in response to food.

This study shows that AgRP neurons regulate context-induced feeding through precise temporal firing patterns during context exposure.

The paper identifies a stress-sensitive anorexigenic pathway from the medial prefrontal cortex to the lateral hypothalamus in mice and shows its role in regulating food intake during stress.

This study shows that impaired metabolic-sensing in AgRP neurons reduces dopamine release in the dorsal striatum and suppresses reward-seeking behavior, especially under hunger.

The paper shows that elevated circulating unacylated-ghrelin impairs hippocampal neurogenesis and memory in mice and is associated with reduced AG:UAG ratio in Parkinson’s disease dementia patients.