Alex Reichenbach

Acute threats modulate hunger circuit dynamics to instruct avoidance behaviour

This study shows that hunger-sensitive AgRP neurons in the hypothalamus are inhibited by threats, leading to avoidance behavior through GABAergic inputs from DMH neurons.

FiPhoPHA - A fiber photometry python package for post-hoc analysis

FiPhoPHA provides a user-friendly Python package for unbiased post-hoc statistical analysis of fiber photometry data, improving reproducibility and standardization.

A simple action reduces high fat diet intake and obesity in mice

This study shows that requiring mice to perform a simple action to access high-fat diet reduces intake and prevents obesity, suggesting that easy access promotes overeating.

Metabolic sensing in AgRP regulates sucrose preference and dopamine release in the nucleus accumbens

This study shows that metabolic sensing in AgRP neurons is essential for dopamine release in the nucleus accumbens in response to caloric solutions and influences sucrose preference under hunger.

Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity.

This study shows that ghrelin signaling in AgRP neurons integrates energy need with sensory cues to regulate AgRP activity and dopamine release in response to food.

Temporal regulation of AgRP neurons mediates context-induced feeding

This study shows that AgRP neurons regulate context-induced feeding through precise temporal firing patterns during context exposure.

Identification of a stress-sensitive anorexigenic neurocircuit from medial prefrontal cortex to lateral hypothalamus.

The paper identifies a stress-sensitive anorexigenic pathway from the medial prefrontal cortex to the lateral hypothalamus in mice and shows its role in regulating food intake during stress.

Metabolic-sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum

This study shows that impaired metabolic-sensing in AgRP neurons reduces dopamine release in the dorsal striatum and suppresses reward-seeking behavior, especially under hunger.

Circulating unacylated-ghrelin impairs hippocampal neurogenesis and memory in mice and is altered in human Parkinson’s disease dementia

The paper shows that elevated circulating unacylated-ghrelin impairs hippocampal neurogenesis and memory in mice and is associated with reduced AG:UAG ratio in Parkinson’s disease dementia patients.