Douglas B. Gould

This study identifies age-associated PKA-dependent remodeling of Ryanodine receptor 2 clusters as a mechanism linking COL4A2 mutations to cerebral artery dysfunction.

This paper introduces a 3D imaging and analysis framework to study retinal microvasculature, revealing layer-associated vulnerability in vascular development and neovascular remodeling.

The paper identifies Fibronectin 1 as a genetic modifier in a Col4a1 mutant mouse model of Gould syndrome, showing it suppresses ocular and muscular phenotypes through increased expression and integrin signaling.