Author

Alfredo Sanchez Solano

University of Rochester MedicineORCID 0000-0002-8218-256XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Scott EarleyiD· 3 shared Boris J. LavanderosiD· 2 shared Cassandre Labelle‐DumaisiD· 2 shared Douglas B. GouldiD· 2 shared Evan YamasakiiD· 2 shared Wanchun ZhuiD· 2 shared Myriam M. ChaumeiliD· 1 shared Pratish ThakoreiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersPhysiology

Scott EarleyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ryanodine receptor cluster remodeling links COL4A2 mutation to cerebral artery dysfunction

Boris J. Lavanderos, Evan Yamasaki, Alfredo Sanchez Solano, Wanchun Zhu, Cassandre Labelle‐Dumais, Yumei Feng Earley, Douglas B. Gould, Scott Earley

This study identifies age-associated PKA-dependent remodeling of Ryanodine receptor 2 clusters as a mechanism linking COL4A2 mutations to cerebral artery dysfunction.

bioRxiv · Oct 1, 2026 · PreprintPhysiology

TRPM4 Couples Mechanical Force to Myogenic Constriction Throughout the Resistance Vasculature

Wanchun Zhu, Alfredo Sanchez Solano, Boris J. Lavanderos, Shiyue Pan, Yumei Feng, Scott Earley

This study demonstrates that TRPM4 channels are essential for mechanotransduction in resistance arteries, mediating pressure-induced smooth muscle cell depolarization and myogenic constriction across cerebral, mesenteric, and skeletal muscle vessels.

bioRxiv · Jun 11, 2026 · PreprintPhysiology

PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease

Pratish Thakore, Evan Yamasaki, Sher Ali, Alfredo Sanchez Solano, Cassandre Labelle‐Dumais, Xiao Pei Gao, Myriam M. Chaumeil, Douglas B. Gould, Scott Earley

Proceedings of the National Academy of Sciences · Aug 22, 2023Peer-reviewedNeuroscience