Cassandre Labelle‐Dumais

Ryanodine receptor cluster remodeling links COL4A2 mutation to cerebral artery dysfunction

This study identifies age-associated PKA-dependent remodeling of Ryanodine receptor 2 clusters as a mechanism linking COL4A2 mutations to cerebral artery dysfunction.

PRSS56 acts as an intrinsic retinal signal driving postnatal ocular axial growth and myopia susceptibility

This study identifies PRSS56 as a retinal factor promoting ocular axial growth and links it to myopia susceptibility through genetic and functional analyses.

PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease

Identification of ADAMTS19 as a novel retinal factor involved in ocular growth regulation

The paper identifies ADAMTS19 as a retinal factor that compensates for impaired ocular growth in PRSS56 and MFRP mutant mice, highlighting its role in axial length regulation.

PRSS56 is required for the developmental positioning of ocular angle structures

This study shows that PRSS56 is essential for proper positioning of ocular angle structures during development, leading to angle closure and elevated intraocular pressure in mice.