Scott Earley

This study identifies age-associated PKA-dependent remodeling of Ryanodine receptor 2 clusters as a mechanism linking COL4A2 mutations to cerebral artery dysfunction.

This study demonstrates that TRPM4 channels are essential for mechanotransduction in resistance arteries, mediating pressure-induced smooth muscle cell depolarization and myogenic constriction across cerebral, mesenteric, and skeletal muscle vessels.

This study identifies a Gαq/11-IP3R1-ANO1 signaling axis responsible for pressure-induced lymphatic contractions in mouse popliteal vessels.

The paper uses PANDORA-seq to identify mitochondrial small RNA changes in an Alzheimer's Disease mouse model, linking them to increased lysosome activity.

The paper identifies TRPA1 channels in brain capillary endothelial cells as key initiators of neurovascular coupling by generating retrograde signals that dilate upstream arterioles.