Author

Yoichi Osawa

University of MichiganORCID 0000-0001-5140-3211Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Cristian Martinez-RamosiD· 1 shared Daniel R. SouthworthiD· 1 shared Eric TseiD· 1 shared H. ZhangiD· 1 shared Jifeng ZhangiD· 1 shared Kanghyun LeeiD· 1 shared Miranda Lau· 1 shared Sun YuDong· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Cristian Martinez-RamosORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintApr 7, 2026

Structural Basis of Electron Transfer by the Human Nitric Oxide Synthase Holoenzyme Complex

Kanghyun Lee, Cristian Martinez-Ramos, Thomas H. Pospiech…·Daniel R. Southworth

This study reveals the structural basis of electron transfer in the human inducible NOS holoenzyme complex using cryo-EM, showing how cofactors are arranged for catalysis.

DOI 10.64898/2026.04.06.716795

humancryo-EM

𝕏 PostBluesky

BiochemistryACS Synthetic BiologyPeer-reviewedMar 6, 2026

Computational design of CYP102A1 variants for the biosynthesis of a next-generation antiplatelet drug DT-678

Sun YuDong, Xiaoqiang Huang, Jifeng Zhang…·H. Zhang

This paper designs CYP102A1 variants to biosynthesize the antiplatelet drug DT-678, showing improved catalytic activity and productivity with ascorbic acid protection.

4 citationstop 2%

proteomicsdeep learning

𝕏 PostBluesky