Timothy J. Hohman

Serpin A3 is Increased in Cerebral Amyloid Angiopathy and ARIA

The paper investigates Serpin A3 expression in cerebral amyloid angiopathy and Alzheimer's disease using single-nucleus transcriptomics and microscopy, finding increased Serpin A3 in affected tissues.

Continuous amyloid staging complements global amyloid burden in early Alzheimer's disease

This paper develops a continuous amyloid staging score from regional amyloid PET to improve early Alzheimer's disease staging and cognitive risk stratification.

Charting Cervical Spinal Cord Morphometry Across the Lifespan

The paper generates lifespan normative charts for cervical spinal cord morphometry using MRI data, revealing non-linear changes and sex differences across ages 0-100.

Automated Segmentation and Tractography of Brainstem and Subcortical White Matter

The paper develops an automated pipeline for segmenting and parcellating brainstem and subcortical white matter pathways using diffusion MRI data.

Single-nucleus transcriptome-wide association study of human brain disorders

This study performs a single-nucleus transcriptome-wide association study to identify gene-trait associations in brain disorders, revealing cell-type-specific genetic regulation and ancestry-specific patterns.

Single-Nucleus Atlas of Cell-Type Specific Genetic Regulation in the Human Brain

The paper constructs a single-nucleus atlas of genetic regulation in the human brain, identifying cell-type-specific regulatory effects and disease-associated genes.

Female-Biased IL-17/STAT3 Signaling Marks Dementia-Associated Microglial Inflammation in Alzheimer's Disease

The paper identifies a female-biased IL-17/STAT3 signaling program in microglia associated with dementia in Alzheimer's disease using single-cell transcriptomics.

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

This study identifies genetic loci and pathways associated with limbic white matter microstructure in aging and Alzheimer's Disease using multi-cohort diffusion MRI and bulk RNA-seq data.

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort

This paper performs a large-scale GWAS meta-analysis of neuropathologic lesions in Alzheimer's disease and related dementias, identifying both known and novel genetic associations.

Lifespan Trajectories of Asymmetry in White Matter Tracts

This study characterizes white matter asymmetry across the lifespan using a large dataset, revealing dynamic changes in asymmetry patterns with age.

Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning

The paper uses machine learning to predict autopsy-confirmed neuropathology from clinical, neuroimaging, and CSF biomarkers, finding that different modalities best predict specific pathologies.

White matter microstructure and macrostructure brain charts across the human lifespan

The paper develops normative reference charts for white matter microstructure and macrostructure across the lifespan using diffusion MRI data from 50 studies.

Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts

The paper evaluates the variability of GAMLSS-based brain charts using analytic and empirical methods, finding low coefficient of variation across most white matter features.

HEXIM1/P-TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization

This study investigates the role of the HEXIM1/P-TEFb complex in regulating RNA polymerase II pause release and immediate early gene induction in neurons during depolarization.

Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's Disease

The paper links PSMC3 expression to Alzheimer's Disease through neuroimaging and genetic analyses, showing its association with brain structure changes and dementia family history.

Post-translational modifications in the brain are critical contributors to Alzheimers disease neuropathology and cognitive decline

This study identifies novel post-translational modifications in Alzheimer's disease brains linked to neuropathology and cognition using mass spectrometry data from 101 participants.

Single Cell Landscape of Sex-specific Drivers of Alzheimers Disease

This study identifies sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive decline using single-nucleus RNA sequencing from human brain tissue.

Blood-based Transcriptomics Reveal Sex- and Amyloid-Modulated Biology of Plasma pTau217 in Preclinical Alzheimer's Disease

The paper identifies gene associations with plasma pTau217 in preclinical Alzheimer's disease, showing modulation by APOEε4, Aβ-PET, and sex, with X-linked genes playing a role.

Evaluation of Deep Learning Algorithms to Predict Multiple Dementia-Related Neuropathologies from Brain MRI, Clinical and Genetic Data

This study evaluates deep learning models that predict multiple dementia-related neuropathologies using MRI, clinical, and genetic data, showing the potential of multimodal AI for non-invasive profiling.

Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance

The paper examines sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive performance using bulk transcriptomic data from 767 individuals.

A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations

This paper develops an APOE-independent polygenic risk score for Alzheimer's disease that shows associations with cognitive decline and neuropathological markers across diverse populations.

Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures

This paper identifies genome-wide pleiotropic loci linking blood pressure and cognitive performance measures using longitudinal data from multiple cohorts.

Advancing Fair and Explainable Machine Learning for Neuroimaging Dementia Pattern Classification in Multi-Ethnic Populations

This study addresses dementia classification bias across ethnic groups using few-shot learning and domain alignment, reducing performance gaps between White American and Hispanic cohorts.

Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults

The paper identifies sex-specific genetic loci associated with memory, executive functioning, and language performance in older adults through genome-wide meta-analyses.

Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset

The paper provides a whole-genome sequencing dataset of 36,361 ADSP participants, including variant annotations, phenotypes, and a linkage disequilibrium panel for Alzheimer's Disease research.

Cognitive resilience to Alzheimers disease in mice depends on gene-diet interactions

This study identifies gene-diet interactions that influence cognitive resilience to Alzheimer's disease in mice, finding a diet-dependent genetic locus associated with resilience.

Evaluating the association of APOE genotype and cognitive resilience in SuperAgers

This study examines the association between APOE genotype and cognitive resilience in SuperAgers, finding lower APOE-ε4 and higher APOE-ε2 frequencies in non-Hispanic White SuperAgers compared to controls and Alzheimer's cases.

Phospholipase D3 regulates lysosomal morphology, biogenesis, and function in neurons.

This study shows PLD3 regulates lysosomal morphology, biogenesis, and function in neurons by affecting protein abundance, subcellular location, and clearance of aggregated proteins.

MidRISH: Unbiased harmonization of rotationally invariant harmonics of the diffusion signal

MidRISH harmonizes diffusion imaging data by projecting sites to a mid-space, reducing reference bias compared to LinearRISH.

Multiomic Evidence for a Unified Model of Alzheimer's Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown