Dongqing Zheng

Kinetic and data-driven modeling of pancreatic β-cell central carbon metabolism and insulin secretion

This paper develops a kinetic and data-driven model of pancreatic β-cell metabolism to understand its role in glucose-stimulated insulin secretion and predict therapeutic interventions.

Identification of a Proteomic Signature of Senescence in Primary Human Mammary Epithelial Cells

The paper identifies a proteomic signature of senescence in primary human mammary epithelial cells using mass spectrometry-based proteomics and integrates it with transcriptomic data.

AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture

The paper shows that AKT, but not MYC, causes cell death in oxidative conditions by increasing reactive oxygen species, revealing a metabolic vulnerability in cancer cells.

Computational model of chimeric antigen receptors explains site-specific phosphorylation kinetics

The paper develops a computational model to explain site-specific phosphorylation kinetics of CARs using phospho-proteomic data and mechanistic modeling.