Peter J. Meikle

A diet enriched in highly poly-unsaturated fatty acids alters immune cell lipid composition and ferroptosis susceptibility

This study shows that a high PUFA diet increases PL-PUFA content in immune cells and enhances their susceptibility to ferroptosis.

Polygenic risk scores for hypertensive disorders of pregnancy and later-life cardiovascular disease in women

This paper investigates if polygenic risk scores for hypertensive disorders of pregnancy are associated with later-life cardiovascular disease outcomes in women.

Nitric oxide synthase inhibition and biological sex define different cardiac responses to cardiometabolic stress in older mice.

This study shows that biological sex and nitric oxide synthase inhibition lead to different cardiac responses to cardiometabolic stress in older mice, resulting in distinct HFpEF-like or HFrEF-like phenotypes.

Ablation of GM3 Gangliosides in cardiomyocytes modestly impacts heart size but does not protect the murine heart against ischemia reperfusion injury

This study shows that removing GM3 gangliosides in cardiomyocytes slightly reduces heart size but does not protect against ischemia-reperfusion injury.

Dual-Lipa: A sequential multi-omic subcellular landscape map of mouse heart

This paper develops a dual-omics workflow to map subcellular proteome and lipidome in mouse heart, revealing sex-dependent molecular differences and conserved subcellular lipid features.

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models

This study identifies SHIP1 ligands with brain exposure and in vivo activity in Alzheimer's models, showing target engagement and reduced neuroinflammation.

Diet- and metabolic state-dependent remodeling of the mouse brain lipidome

This study shows that the mouse brain lipidome changes with diet and metabolic state, particularly highlighting the impact of high-fat diets on lipid remodeling in the hypothalamus and brainstem.

Multi-omics discovery of hallmark protein and lipid features of circulating small extracellular vesicles in humans

The paper identifies hallmark protein and lipid features of circulating extracellular vesicles in humans using multi-omics analysis and provides an open-source tool for further exploration.

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

This study shows that CASP1 self-cleavage terminates its activity in vivo, maintaining homeostasis and preventing inflammasome-driven diseases.

Skeletal Muscle Specific PolG Dysfunction Activates the Integrated Stress Response and Promotes a Cachexia like Phenotype

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

Multiomic Evidence for a Unified Model of Alzheimer's Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown

Comprehensive genetic analysis of the human lipidome identifies novel loci controlling lipid homeostasis with links to coronary artery disease

This study identifies 667 genetic loci associated with lipid species and links 186 of them to coronary artery disease through integrative lipidomics and genomics.

A functional variant of the SIDT2 gene involved in cholesterol transport is associated with HDL-C levels and premature coronary artery disease.

Developmental and Intergenerational Landscape of Human Circulatory Lipidome and its Association with Obesity Risk

The paper maps the developmental and intergenerational changes in the human circulatory lipidome and identifies lipid signatures associated with obesity risk in mothers and offspring.

Detailed metabolic phenotyping of four tissue specific Cas9 transgenic mouse lines

This study demonstrates that long-term tissue-specific Cas9 expression in mice does not cause detrimental health effects or metabolic changes, supporting its use for gene-specific studies.

The Alzheimer’s Disease Metabolome: Effects of Sex and APOE ε4 genotype

The paper investigates sex and APOE ε4 genotype effects on metabolic alterations in Alzheimer’s disease using stratified analysis of serum metabolites.

Sets of Co-regulated Serum Lipids are Associated with Alzheimer Disease Pathophysiology

The paper identifies lipid sets in blood associated with Alzheimer's disease biomarkers and clinical symptoms using lipidomic profiling in the ADNI1 cohort.