Swati Sharma

Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in mice.

This study creates a mouse model with a thrombin-insensitive PAR4 receptor, showing reduced thrombosis but normal responses to PAR4 agonists.

Cyto-architecture constrains a photoactivation induced tubulin gradient in the syncytial Drosophila embryo

The paper uses photoactivation to study how cyto-architecture constrains the spread of cytoplasmic and tubulin molecules in Drosophila embryos, showing that tubulin gradients are more restricted by microtubules and plasma membrane structure.