Matthew J. Flick

This study shows that AQP4 regulates edema, maintains astrocyte differentiation, and limits immunosuppressive changes in glioblastoma.

This study identifies extravascular coagulation as a regulator of fibrotic stromal states in PDAC via tumor-intrinsic PAR1 signaling, showing PAR1 inhibition can reprogram the tumor-promoting stroma.

This study creates a mouse model with a thrombin-insensitive PAR4 receptor, showing reduced thrombosis but normal responses to PAR4 agonists.

This study evaluates POmAb, an anti-prothrombin antibody, in mice showing it reduces thrombin generation and fibrin formation without excessive bleeding.

This study shows that fibrin accumulation in a catheterized bladder promotes anti-inflammatory macrophage polarization, which impairs antimicrobial responses and allows bacterial persistence in UTIs.