The Heat shock protein 70 machinery is crucial in the production of infectious chikungunya virus progeny
Marleen van der Laan, Sam Verwimp, Oleta T. Johnson, Ellen M. Bouma, Katrien Trappeniers, Frederique Visscher, Heidi H. van der Ende-Metselaar, Denise P.I. van de Pol, Leen Delang, Jason E. Gestwicki, Harm H. Kampinga, Jolanda M. Smit
This study shows that inhibiting Hsp70 reduces chikungunya virus infectious particle production without harming host cells.
bioRxiv · Jan 26, 2026 · PreprintMicrobiology