Distinct Effects of the Extracellular Matrix on Tumor Organization and Response to Cancer Virotherapy
Ilaria Supino, Frederique Visscher, Annemarie Boerma, Anne K. Wouters, Manas Joshi, Mirjam H.M. Heemskerk, Darshak Bhatt
The paper examines how ECM composition and abundance affect tumor organization and response to Alphavirus replicon-based virotherapy using computational modeling and 3D tumor spheroid-immune co-cultures.
bioRxiv · Jul 21, 2026 · PreprintCancer Biology