Sander Verheule

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.

The paper identifies proteomic signatures of mitochondrial dysfunction in goats with atrial fibrillation, highlighting oxidative phosphorylation subunits and HSPA9 as a regulatory hub.

This study investigates the distribution and function of atrial granules in guinea pig and goat cardiomyocytes, finding they are acidic calcium stores closely associated with the sarcoplasmic reticulum and increase in number during atrial fibrillation.

The paper uses proteomics and other methods to study endolysosomal changes in a goat model of atrial fibrillation, identifying upregulated pathways and specific proteins.