Daniel Aston

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.

This study investigates the distribution and function of atrial granules in guinea pig and goat cardiomyocytes, finding they are acidic calcium stores closely associated with the sarcoplasmic reticulum and increase in number during atrial fibrillation.

This study shows that lysosomal calcium signaling via NAADP and calcium-stimulated adenylyl cyclase 1 and 8 contributes to the acute α-adrenergic response in atrial myocytes.

The paper uses proteomics and other methods to study endolysosomal changes in a goat model of atrial fibrillation, identifying upregulated pathways and specific proteins.