Lee‐Yuan Liu‐Chen

This study shows that KOR phosphorylation does not affect U50,488H-induced corticosterone increase or diuresis in mice, with males showing greater diuresis than females.

This study shows that KORs in aPVT neurons mediate morphine withdrawal, anxiety, and fear in both sexes, but only contribute to KOR agonist-induced aversion in males.

This paper introduces a framework to stratify pharmacological data by action type and assay readout, improving QSAR model validity for opioid receptors.

This study shows that paternal morphine exposure increases morphine self-administration in male offspring but not females, with region-specific neural changes in reward-related brain areas.

The paper develops a MOR-specific Cre mouse line to study opioid receptor cell types and their molecular characteristics during opioid withdrawal.