Jordi Creus‐Muncunill

This study shows that deleting TYROBP in HD mice reduces microglial activation and improves motor deficits without correcting neuronal gene expression.

The paper develops a MOR-specific Cre mouse line to study opioid receptor cell types and their molecular characteristics during opioid withdrawal.

The paper identifies Foxf2 and Olig2 as key transcription factors regulating striatal compartmentation and neuronal differentiation through RNA- and ATAC-seq analysis of murine striosomes and matrix.

This study shows that RTP801 mediates motor learning dysfunction in Huntington's disease by affecting synaptic plasticity, suggesting a therapeutic target through the RTP801/Akt/mTOR pathway.

This study shows increased lamin B1 levels in HD neurons disrupt nuclear function, and reducing lamin B1 with betulinic acid improves nuclear homeostasis and prevents motor and cognitive dysfunction in a mouse model.