Emmanuel Haillot

This study shows that loss of Twist in Nematostella vectensis impairs tentacle development and causes epithelial neoplasia, highlighting its role in tissue patterning and homeostasis.

The paper shows that BMP signaling is downstream of ERK1/2 in Spiralia and is involved in dorsoventral development, but this hierarchy is lost in annelids with autonomous development.

The paper shows Notch signaling coordinates germ layer formation and axial polarity in sea anemone gastruloids through a feedback loop with Wnt signaling.

The paper investigates the specification of three germ layers in Nematostella vectensis, showing that MAPK, β-catenin, and Notch signaling segregate mesoderm and endoderm, suggesting triploblasty predates cnidarian-bilaterian divergence.

The paper develops a computational model of the Nodal and BMP2/4 signaling pathways in sea urchin embryos, showing BMP dominance and the importance of Smad activation rates in dorsal-ventral patterning.