Swann Floc’hlay

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

The paper quantifies how cis-acting genetic variation affects chromatin accessibility, histone modifications, and gene expression in Drosophila embryos, finding that much of this variation does not propagate to gene expression.

The paper develops a computational model of the Nodal and BMP2/4 signaling pathways in sea urchin embryos, showing BMP dominance and the importance of Smad activation rates in dorsal-ventral patterning.