Author

James J. Siclari

The Graduate Center, CUNYORCID 0000-0001-5275-4515Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Denize C. FavaroiD· 2 shared Kevin H. GardneriD· 2 shared Alec H. FollmeriD· 1 shared Cullen RoederiD· 1 shared Eta A. IsiorhoiD· 1 shared Malvin ForsoniD· 1 shared Martha L. BulykiD· 1 shared Richard H. HuangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

Denize C. FavaroORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 3, 2026

Structural Basis of a Novel Heme Binding Bacterial One-Component Switch

James J. Siclari, Malvin Forson, Cullen Roeder…·Kevin H. Gardner

This paper characterizes FG214, a heme-binding one-component switch from Fimbriimonas ginsengisoli, showing heme redox state controls monomer-dimer transitions and DNA binding.

DOI 10.64898/2026.03.15.711900

bacteria (other)structural biology

𝕏 PostBluesky

BiochemistryProtein SciencePeer-reviewedOct 11, 2025

A Pipeline for Screening Small Molecule-Enhanced Protein Stability in A Bacterial Orphan Receptor

James J. Siclari, Denize C. Favaro, Richard H. Huang, Kevin H. Gardner

The paper identifies small molecule ligands that stabilize a bacterial PAS-HTH transcription factor, CU228, using a combination of bioinformatics, thermal stability assays, and NMR.

DOI 10.1002/pro.70330

bacteria (other)proteomics

𝕏 PostBluesky