Xuan Xie

The paper identifies two distinct engram ensembles within striatal medium spiny neurons that encode opposing memories for alcohol relapse and extinction.

The paper shows that direct pathway neurons in the striatum induce an acetylcholine dip-rebound that encodes action-outcome contingency during learning.

This paper identifies hyperactivity in the mPFC-to-DMS circuit in 5xFAD mice as a cause of cognitive inflexibility, showing that inhibiting this circuit improves cognitive function and reduces Aβ accumulation.