Author

Xuehua Wang

Texas A&M Health Science Center

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Biology Disciplines

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Neuroscience· 7

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Approach:experimental assay· 7 Organism:mouse· 7 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:electronic health records· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Jun WangiD· 6 shared Himanshu GangaliD· 4 shared Xueyi XieiD· 4 shared Xuan XieiD· 3 shared Zhenbo HuangiD· 3 shared Rachel J. SmithiD· 2 shared Ruifeng Chen· 2 shared Ruifeng CheniD· 2 shared

Activity by Year

2021-2026 · peak 6/yr

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10 top collaborators · 38 mutual co-author links

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6 shared papersNeuroscience

Jun WangORCID

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7 papers

Recent·Most cited

Subregion-Specific Input Organization of Prefrontal-Projecting Basal Forebrain Cholinergic Neurons and Weakened Striatum-to-NBM Inhibitory Transmission in 5xFAD mice

Yufei S. Huang, Xueyi Xie, Michael Fernaine, Ziyi Li, Xuehua Wang, Jun Wang

The paper maps input organization of mPFC-projecting basal forebrain cholinergic neurons and identifies weakened striatal-NBM inhibitory transmission in 5xFAD mice.

Neurobiology of Disease · Sep 8, 2026Peer-reviewedNeuroscience

Extended Amygdala CRF Projections to Striatal Striosomes Potentiate Dopamine Suppression During Fentanyl Withdrawal

Xueyi Xie, Amanda Essoh, Ruifeng Chen, Xuehua Wang, Jun Wang

This paper identifies a CRF pathway in the extended amygdala that enhances striosomal suppression of dopamine during fentanyl withdrawal.

bioRxiv · Jun 26, 2026 · PreprintNeuroscience

Extinction Training Suppresses Alcohol Relapse by Inhibiting Acquisition-Recruited Striatal Ensembles and Engaging Striosomal Neurons

Xueyi Xie, Xuehua Wang, J C Wang

This study shows that extinction training reduces alcohol relapse by suppressing acquisition-recruited striatal ensembles and engaging striosomal neurons in mice.

bioRxiv · May 5, 2026 · PreprintNeuroscience

Dual Engram Architecture within a Single Striatal Cell Type Distinctly Controls Alcohol Relapse and Extinction

Xuan Xie, Yufei Huang, Ruifeng Chen, Zhenbo Huang, Himanshu Gangal, Ziyi Li, Jiayi Lu, Adelis M. Cruz, Anita Chaiprasert, Emily Yu, Nicholas Hernandez, Valerie Vierkant, Runmin Wang, Xuehua Wang, R MAINS SMITH, Jun Wang

The paper identifies two distinct engram ensembles within striatal medium spiny neurons that encode opposing memories for alcohol relapse and extinction.

Neuron · Apr 14, 2026Peer-reviewedNeuroscience

Striatal Acetylcholine Dip-Rebound Is Induced by Direct Pathway Neurons and Encodes Action-Outcome Contingency

Ruifeng Chen, Xuan Xie, Himanshu Gangal, Xuehua Wang, Jun Wang

The paper shows that direct pathway neurons in the striatum induce an acetylcholine dip-rebound that encodes action-outcome contingency during learning.

bioRxiv · Jan 14, 2026 · PreprintNeuroscience

Early-Stage Corticostriatal Circuit Hyperactivity Impairs Cholinergic Function and Cognitive Flexibility in an Alzheimer's Model

Yufei S. Huang, Xuan Xie, Zhenbo Huang, Ruifeng Chen, Himanshu Gangal, Xuehua Wang, Karienn A. de Souza, Julia Hunter, Xin Yi Wu, Doodipala Samba Reddy, Jeannie Chin, Jun Wang

This paper identifies hyperactivity in the mPFC-to-DMS circuit in 5xFAD mice as a cause of cognitive inflexibility, showing that inhibiting this circuit improves cognitive function and reduces Aβ accumulation.

bioRxiv · Jan 14, 2026 · PreprintNeuroscience

Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility

Tengfei Ma, Zhenbo Huang, Xueyi Xie, Yifeng Cheng, Xiaowen Zhuang, Matthew J. Childs, Himanshu Gangal, Xuehua Wang, Laura N. Smith, Rachel J. Smith, Yubin Zhou, Jun Wang

This study shows chronic alcohol consumption impairs cognitive flexibility by reducing thalamic excitation of cholinergic neurons in the dorsomedial striatum.

Journal of Clinical Investigation · Dec 23, 2021Peer-reviewedNeuroscience