Sarah E. Cobey

This study compares neutralizing antibody titers from egg-derived and recombinant protein influenza vaccines against diverse H1N1 strains, finding that egg-derived vaccines induce less boost against a new clade with specific antigenic mutations.

The paper quantifies how respiratory pathogens return to pre-pandemic dynamics after interventions, finding that susceptible population replenishment rates determine their resilience to perturbations.

This paper develops a framework to predict pathogen mutual invasibility and co-circulation using ecological theory, finding near-universal mutual invasibility across major pathogen systems.

This study develops a high-throughput sequencing-based neutralization assay to measure antibody titers against multiple influenza strains and finds that vaccination effects vary by individual and prior vaccination history.

The paper derives constraints on serial strain replacement in pathogens, showing that original antigenic sin limits diversity and imposes a 'speed limit' on strain evolution.