Charlotte Jessica E. Metcalf

The paper models future congenital Toxoplasmosis burden in Africa under climate and demographic changes, finding that reduced infection incidence may increase disease severity due to later infections during pregnancy.

This paper develops a mathematical model to understand how early-life secretory IgA and gut microbiome interactions shape immune tolerance and homeostasis.

The paper develops a stochastic framework to model how immunity influences viral adaptation rates, showing how parameters like immunity strength and transmissibility shape phylodynamic curves and escape variant emergence risks.

This paper develops a framework to predict pathogen mutual invasibility and co-circulation using ecological theory, finding near-universal mutual invasibility across major pathogen systems.

This study investigates why holometabolous insects evolved a pupal stage, finding that rapid growth and a trade-off between growth and differentiation favor this life history under high mortality.